.png | CAS_number = 53-19-0 | ATC_prefix = L01 | ATC_suffix = XX23 | ATC_supplemental = | PubChem = 4211 | DrugBank = APRD00494 | chemical_formula = C₁₄H₁₀Cl₄ | molecular_weight = 320.04 g/mol | bioavailability = | protein_bound = 6% | metabolism = | elimination_half-life = 18-159 days | pregnancy_category = | legal_status = | routes_of_administration = }} Mitotane is a substance used for the rare disease adrenocortical carcinoma.

It has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug due to the small number of patients in need of it. Its administration occurs in cases where the tumour cannot be surgically omitted.

Mitotane alternates steroides peripheral metabolism, represses directly the adrenal cortex and alternates cortisone metabolism. It is an isomere chemically to DDT.

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toxicology: Chiral effects in adrenocorticolytic action of o,p′-DDD (mitotane) in human adrenal cells: Xenobiotic... http://bit.ly/8oR7D5
Toxicology_IPS (Toxicology Research) Mon, 04 Jan 2010 10:27:08 -0000
toxicology: Chiral effects in adrenocorticolytic action of o,p′-DDD (mitotane) in human adrenal cells: Xenobiotic... http://bit.ly/8oR7D5

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