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Milrinone is a peak III cAMP-inhibitor. It has positive inotropic, vasodilating and minimal chronotropic effects. It is used in the management of heart failure only when conventional treatment with vasodilators, digitalis and diuretics has proven insufficient. This is due to the potentially fatal adverse effects of milrinone, including ventricular arrhythmias.
Whereas beneficial hemodynamic (US English)/ haemodynamic (British English) effects are shown (at least short-term), several studies have shown no or a negative effect on mortality rates of hospitalized patients receiving milrinone.
See also
- Phosphodiesterase inhibitor More on [ Milrinone ]
Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts.
pubmedstream (pubmedstream) Sun, 05 Feb 2012 06:48:16 -0000
Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts.
Primacor ( Milrinone Lactate Injection ) - A phosphodiesterase inhibitor (PDE III) that is indicated for the short-term intravenous treatment of patients with acute decompensated heart failure. Site provides information for health care professionals and patients.
