Mifepristone is a synthetic steroid with anti-progestagenic and anti-glucocorticoid effects. It is useful in humans as an abortifacient in the first two months of pregnancy, as well as medical treatment for certain endocrine conditions. During early trials, it was known as RU-486 after its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, but other countries then followed suit, often amid controversy. In the United States it is made by Danco Laboratories under the tradename Mifeprex. (In the United States, at least, the drug is still commonly referred to as "RU-486".)

Chemical Description

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Mifepristone is a light yellow powder, highly soluble in methanol and only poorly soluble in water. Its structural name is 11β-^*-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one. Its empirical formula is C₂₉H₃₅NO₂

Pharmacology

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During early pregnancy, the endometrium is dependent upon progestagenic support from the corpus luteum. Mifepristone acts as a competitive inhibitor at the progesterone receptor and thus removes this basis for support. In addition, it sensitises the myometrium to the contraction-inducing activity of prostaglandins.

More on [ Mifepristone ]

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