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Mifepristone is a synthetic steroid with anti-progestagenic and anti-glucocorticoid effects. It is useful in humans as an abortifacient in the first two months of pregnancy, as well as medical treatment for certain endocrine conditions. During early trials, it was known as RU-486 after its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, but other countries then followed suit, often amid controversy. In the United States it is made by Danco Laboratories under the tradename Mifeprex. (In the United States, at least, the drug is still commonly referred to as "RU-486".)

Chemical Description


Mifepristone is a light yellow powder, highly soluble in methanol and only poorly soluble in water. Its structural name is 11β-*-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one. Its empirical formula is C29H35NO2

Pharmacology


During early pregnancy, the endometrium is dependent upon progestagenic support from the corpus luteum. Mifepristone acts as a competitive inhibitor at the progesterone receptor and thus removes this basis for support. In addition, it sensitises the myometrium to the contraction-inducing activity of prostaglandins.

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Reproductive Health
RU 486 and Medical Abortion
RU 486 and Medical Abortion :: Abortion

 
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YourNightmares_ (Your Nightmare) Sun, 08 Jan 2012 05:11:22 -0000
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MISOPROSTOL (CYTO) + MIFEPRISTONE (MIFEPREX) http://t.co/g1mb31N6
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MISOPROSTOL (CYTO) + MIFEPRISTONE (MIFEPREX) http://t.co/g1mb31N6
Mifepristone을 성교한후 복용하면 착상된 수정란을 낙태시키는 작용이있다. 성교후 바로 Progestin levonorgestrel 1 정을 복용하면 배란이 연기되든지 배란이 되지 않게 해서 임신이 안 되게 하는 최신 응급피임약이다 부모도반의
drleesangwon ( 이상원 ) Sat, 07 Jan 2012 13:00:20 -0000
Mifepristone을 성교한후 복용하면 착상된 수정란을 낙태시키는 작용이있다. 성교후 바로 Progestin levonorgestrel 1 정을 복용하면 배란이 연기되든지 배란이 되지 않게 해서 임신이 안 되게 하는 최신 응급피임약이다 부모도반의
Anonymous asked: You may want to add that mifepristone, if access is available, should be taken 1-2 days... http://t.co/wePGKeqy
STFUFauxminists (Megan Milanese) Tue, 03 Jan 2012 06:30:14 -0000
Anonymous asked: You may want to add that mifepristone, if access is available, should be taken 1-2 days... http://t.co/wePGKeqy
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@honda_os Mifepristone - for Abortion, Gossypol - Male contraceptive.
MrReevo ((Diego S.)) Sun, 01 Jan 2012 00:12:24 -0000
@honda_os Mifepristone - for Abortion, Gossypol - Male contraceptive.

 
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DrugDigest: Mifepristone ( Mifeprex ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.

FDA Approves Mifepristone for the Termination of Early Pregnancy - Press release announcing the approval decision.
Meta Description: [ The Food and Drug Administration today approved mifepristone (trade name Mifeprex) for the termination of early pregnancy, defined as 49 days or less, counting from the beginning of the last menstrual period. ]

FDA Mifepristone Information - Official information about the U.S. government's review and approval of mifepristone (RU-486).
Meta Description: [ Mifeprex (mifepristone) Information ]

Mifeprex: The Early Option Pill - Official site of Danco Laboratories. Prescription information, patient guide, news, and history.

Mifepristone - Fact sheets in English and Spanish.
Meta Description: [ Planned Parenthood ]

Mifepristone Overview - Includes history and references to clinical studies.
Meta Description: [ NAF's professional and continuing medical education programs and resources provide health care professionals with evidence- and outcomes-based information about the provision of abortion services ]

The Medical Uses of Mifepristone - Feminist Majority Foundation fact sheet about several serious medical conditions which mifepristone (formerly known as RU-486) may be effective in treating.
Meta Description: [ The Feminist Majority Foundation works for social and political and economic equality for women by using research and education to improve women's lives. The Feminist Majority Foundation Online features daily feminist news with 'take action' ideas, domestic violence and sexual assault hotlines, a... ]

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New Safety Information for Mifepristone (Oct 2005)
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