Methyldopa or alpha-methyldopa (brand names Aldomet®, Apo-Methyldopa®, Dopamet®, Novomedopa®) is a centrally-acting adrenergic antihypertensive medication. It use is now depreciated following introduction of alternative safer classes of agents. However it continues to have a role in otherwise difficult to treat hypertension and pregnancy-induced hypertension.

Mechanism of action

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Methyldopa has variable absorption from the gut of approximately 50%. It is metabolized in the intestines and liver; its metabolite alpha-methylnorepineprine acts in the brain to stimulate alpha-adrenergic receptors decreasing total peripheral resistance. It is excreted in urine.

Methyldopa, in its active metabolite form, leads to increased alpha-2 receptor-mediated inhibition of SNS (centrally and peripherally), allowing PSNS tone to increase. Such activity leads to a decrease in total peripheral resistance (TPR) and cardiac output.

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HTN in pregnancy safe meds: - Methyldopa - Labetalol - Hydralazine - Mg sulphate (preeclampsia).
TweetsMed (Medical Tweets) Fri, 27 Jan 2012 17:13:29 -0000
HTN in pregnancy safe meds: - Methyldopa - Labetalol - Hydralazine - Mg sulphate (preeclampsia).
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