Methotrexate (rINN) (IPA: ), abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid.

History

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Methotrexate originated in the 1940s when Sidney Farber at Children's Hospital Boston was testing the effects of folic acid on cancer. That inspired chemists at the drug company Lederle to start looking for antimetabolites resembling folate. The result was methotrexate, which was developed in 1948. Methotrexate gained Food and Drug Administration (FDA) approval as an oncology drug in 1953.

Uses

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Methotrexate was originally used, as part of combination chemotherapy regimens, to treat many kinds of cancers. It is still the mainstay for the treatment of many neoplastic disorders including acute lymphoblastic leukemia.

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Methotrexate - Twitter Search

Took the methotrexate early & am praying that it won't make me as sick as it did last wk. Injection is also 2nite. Hope I don't 4get.
MikeEnglishFan (Karen Williams) Fri, 18 Dec 2009 22:40:33 -0000
Took the methotrexate early & am praying that it won't make me as sick as it did last wk. Injection is also 2nite. Hope I don't 4get.
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ow_lungs_and_re (OrganizedWisdom) Fri, 18 Dec 2009 17:04:56 -0000
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ow_lungs_and_re (OrganizedWisdom) Fri, 18 Dec 2009 17:04:55 -0000
Trexall Drug Identifiers: Drug identifiers, or pill identifiers, are tools used to identify Trexall (methotrexate) ... http://bit.ly/6FY8Bu
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ow_lungs_and_re (OrganizedWisdom) Fri, 18 Dec 2009 17:04:54 -0000
Trexall Meds for Arthritis Pictures: Pictures or images of Trexall (methotrexate) may be helpful to identify this d... http://bit.ly/706gNf
Trexall Pill Identifiers: Pill identifiers, or drug identifiers, are tools used to identify Trexall (methotrexate) ... http://bit.ly/8YSmsP
owBreastCancer (OrganizedWisdom) Fri, 18 Dec 2009 15:43:24 -0000
Trexall Pill Identifiers: Pill identifiers, or drug identifiers, are tools used to identify Trexall (methotrexate) ... http://bit.ly/8YSmsP
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owBreastCancer (OrganizedWisdom) Fri, 18 Dec 2009 15:43:23 -0000
Trexall Drug Identifiers: Drug identifiers, or pill identifiers, are tools used to identify Trexall (methotrexate) ... http://bit.ly/4CLECp

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