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Mesalazine (BP), also known as Mesalamine (USAN) or 5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug used to treat inflammation of the digestive tract (Crohn's disease) and mild to moderate ulcerative colitis. Mesalazine is a bowel-specific aminosalicylate drug that is metabolized in the gut and has its predominant actions there, thereby having fewer systemic side effects.
As a derivative of Salicylic acid, 5-ASA is also an antioxidant that traps free radicals, which are potentially damaging by-products of metabolism. Under the Radical Induction Theory of Ulcerative Colitis, 5-ASA is functioning as a free radical trap as well as an anti-inflammatory drug.
5-ASA is considered the active moiety of Sulfasalazine, which is metabolized to it.
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Asacol - General and product information about this sulfa-free medication for mild to moderate flare-ups of ulcerative colitis. From Procter and Gamble Pharmaceuticals.
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