Pethidine (INN) or meperidine (USAN) (also referred to as: isonipecaine; lidol; operidine; pethanol; piridosal; Algil^®; Alodan^®; Centralgin^®; Demerol^®; Dispadol^®; Dolantin^®; Dolestine^®; Dolosal^®; Dolsin^®; Mefedina^®) is a fast-acting opioid analgesic drug. In the United States, it is more commonly known as meperidine or by its brand name Demerol.

Pethidine is used to deal with moderate to severe pain, and is delivered as hydrochloride tablets, as a syrup, or by intramuscular or intravenous injection. Because pethidine has the potential to be both physically and psychologically habituating, it is important that it be used in only the doses prescribed, and that withdrawal from the drug be supervised by a physician to ensure there are no adverse reactions.

Mode of action

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Main article: opioid

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