Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. It is marketed by Abbott as Kaletra®, a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS.

As of 2006, lopinavir/ritonavir forms part of the preferred combination for first-line therapy recommended by the US DHHS.DHHS panel. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents (May 4, 2006). (Available for download from AIDSInfo) It is available as capsules, tablets and oral solution.

History

---

Lopinavir was developed by Abbott in an attempt to improve on the HIV resistance and serum protein-binding properties of the company's earlier protease inhibitor, ritonavir.Sham HL, Kempf DJ, Molla A, et al. (1998) ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob. Agents Chemother. 42: 3218-24 Administered alone, lopinavir has insufficient bioavailability; however, like several HIV protease inhibitors, its blood levels are greatly increased by low doses of ritonavir, a potent inhibitor of cytochrome P450 3A4. Abbott therefore pursued a strategy of co-administering lopinavir with sub-therapeutic doses of ritonavir, and lopinavir is only marketed as a co-formulation with ritonavir.

More on [ Lopinavir ]

Lopinavir - Twitter Search

Formulation preference, tolerability and quality of life assessment following a switch from lopinavir/ritonavir.. http://bit.ly/7NWni4
zampbioworld (zampbioworld) Tue, 22 Dec 2009 20:29:35 -0000
Formulation preference, tolerability and quality of life assessment following a switch from lopinavir/ritonavir.. http://bit.ly/7NWni4
drug interaction darunavir/ritonavir & lopinavir/ritonavir on gsk2248761 pk & cyp450 prob drugs http://bit.ly/58pF1J
localtrials (US Clinical Trials ) Sat, 19 Dec 2009 05:42:40 -0000
drug interaction darunavir/ritonavir & lopinavir/ritonavir on gsk2248761 pk & cyp450 prob drugs http://bit.ly/58pF1J
drug interaction darunavir/ritonavir & lopinavir/ritonavir on gsk2248761 pk & cyp450 prob drugs http://bit.ly/58pF1J
usclinicaltrial (US Clinical Trials) Sat, 19 Dec 2009 05:22:40 -0000
drug interaction darunavir/ritonavir & lopinavir/ritonavir on gsk2248761 pk & cyp450 prob drugs http://bit.ly/58pF1J
drug interaction darunavir/ritonavir & lopinavir/ritonavir on gsk2248761 pk & cyp450 prob drugs http://bit.ly/58pF1J
recruitingtrial (Recruiting Trials) Sat, 19 Dec 2009 04:26:49 -0000
drug interaction darunavir/ritonavir & lopinavir/ritonavir on gsk2248761 pk & cyp450 prob drugs http://bit.ly/58pF1J
drug interactions of echinacea, ginseng, & ginkgo biloba taken w/ lopinavir/ritonavir in healthy volunteers http://bit.ly/78kBhM
localtrials (US Clinical Trials ) Fri, 18 Dec 2009 10:34:39 -0000
drug interactions of echinacea, ginseng, & ginkgo biloba taken w/ lopinavir/ritonavir in healthy volunteers http://bit.ly/78kBhM
drug interactions of echinacea, ginseng, & ginkgo biloba taken w/ lopinavir/ritonavir in healthy volunteers http://bit.ly/78kBhM
usclinicaltrial (US Clinical Trials) Fri, 18 Dec 2009 10:14:43 -0000
drug interactions of echinacea, ginseng, & ginkgo biloba taken w/ lopinavir/ritonavir in healthy volunteers http://bit.ly/78kBhM

Subscribe to Lopinavir RSS feed