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Loperamide, usually as hydrochloride, is a drug effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically under brand names such as Lopex®, Imodium®, Dimor® and Pepto® Diarrhea Control.
Mode of action
Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids.
It works by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.
More on [ Loperamide ]
DrugDigest: Loperamide ( Imodium ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Imodium - Loperamide HCl. Provides product information and savings coupon for Canadian consumers as well as diarrhea information, FAQs, interactive features, and tips. [Information in English and French]
Imodium A-D - Previously available only by prescription, Imodium A-D has been used for years to treat diarrhea. (Loperamide)
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