Lisinopril (lye-SIH-no-pril, is a drug of the angiotensin converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes.
Historically, lisinopril was the third ACE inhibitor, after captopril and enalapril that was introduced into therapy in early 1990s. Lisinopril has a number of properties that distinguish it from other ACE inhibitors: it is hydrophilic, has long half life and tissue penetration and is not metabolized by the liver.
Pharmacology
Lisinopril is the lysine-analog of enalapril. Unlike other ACE inhibitors lisinopril is not a prodrug and excreted unchanged in the urine. In cases of overdosage, it can be removed from circulation by
dialysis.
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[ Lisinopril ]
ACE Inhibitors :: Antihypertensives
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DrugDigest: Lisinopril ( Prinivil, Zestril ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.