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Letrozole (Femara®) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer.
Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letrozole blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome p450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids. In contrast, the antiestrogenic action of Tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production.
FDA-approved use
Letrozole is approved by the Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women. Side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis. More on [ Letrozole ]
mk-0752 in combo w/ tamoxifen or letrozole 2 treat early stage breast cancer http://bit.ly/5m7rlO
breastctrials (Breast Cancer Trials) Thu, 03 Dec 2009 08:04:32 -0000
mk-0752 in combo w/ tamoxifen or letrozole 2 treat early stage breast cancer http://bit.ly/5m7rlO
RT @cancer_news the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal http://is.gd/5a0ik
drOncol (Noushin Hart MD) Thu, 03 Dec 2009 07:27:34 -0000
RT @cancer_news the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal http://is.gd/5a0ik
breast cancer prevention by letrozole in high risk women http://bit.ly/7dDoTs
chicagotrials (chicago trials) Thu, 03 Dec 2009 06:51:53 -0000
breast cancer prevention by letrozole in high risk women http://bit.ly/7dDoTs
biomrkrs in predicting response 2 tamoxifen & letrozole in postmenopausal women w/ primary breast cancer tre8d on http://bit.ly/70CTU7
breastctrials (Breast Cancer Trials) Thu, 03 Dec 2009 05:19:03 -0000
biomrkrs in predicting response 2 tamoxifen & letrozole in postmenopausal women w/ primary breast cancer tre8d on http://bit.ly/70CTU7
breast cancer prevention by letrozole in high risk women http://bit.ly/8yVe08
breastctrials (Breast Cancer Trials) Thu, 03 Dec 2009 03:19:34 -0000
breast cancer prevention by letrozole in high risk women http://bit.ly/8yVe08
Stopped taking turinabol after 5 months and letrozole. I might take letrozole at 0.25mg 2x week or even less often.
Bionixx (THE DONSTER-DPerdue) Thu, 03 Dec 2009 03:06:48 -0000
Stopped taking turinabol after 5 months and letrozole. I might take letrozole at 0.25mg 2x week or even less often.
DrugDigest: Letrozole ( Femara ) - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
Femara - Product information for US residents and health care professionals.
Meta Description: [ Breast Cancer FEMARA - post-tamoxifen treatment for post menopausal women with early stage breast cancer ]
Femara ( Letrozole ) - Offers patient and prescribing information from the manufacturer.
Meta Description: [ Novartis Pharmaceuticals Canada Inc. - Our Products - Femara ]
Femara International - Official international pharmaceutical website with information for patients and health professionals.
Meta Description: [ Femara is indicated for the treatment of early breast cancer in postmenopausal women who have completed prior standard tamoxifen therapy. On Femarainfo.com Novartis Oncology provides international healthcare professionals with patient case studies and education materials as well as information on... ]
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