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Labetalol (Normodyne®, Trandate®, fixed combination with hydrochlorothiazide: Normozyde®) is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
It has a particular indication in the treatment of pregnancy-induced hypertension.
Administration
Labetalol is available in 100, 200, and 300 mg tablets and intravenously (only as Trandate®) in 5 mg/ml solution. Adults taking tablets usually start with 100 mg two times a day, with a maximum of 2.4 g/day. In an emergency situation, this may be higher. By IV, the patient is usually started at 2 mg/minute or 20 mg, with a maximum of 300 mg. More on [ Labetalol ]
Beta Blockers :: Drugs and Medications
DrugDigest: Labetolol ( Normodyne, Trandate ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Trandate - Product information from Glaxo Wellcome, in Portable Document Format (PDF). (labetalol hydrochloride)
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