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Isotretinoin (INN) (IPA: ) is a medication used for the treatment of severe acne. It is a retinoid, meaning it is derived from vitamin A and is found in small quantities naturally in the body. Oral isotretinoin is marketed under various trade names, most commonly Accutane or Roaccutane (Roche); while topical isotretinoin is most commonly marketed under the trade names Isotrex or Isotrexin (Stiefel).
History
Prior to the development of isotretinoin, the mainstay treatment of severe acne was oral antibiotics such as the tetracyclines and erythromycin. While these drugs have proven efficacy, they worked against only one contributing factor of acne – the Propionibacterium acnes bacteria. The antibiotics gradually became less effective over time as more resistant strains of the bacterium became prominent.
An early, effective treatment of acne was high doses of the fat-soluble vitamin A. At these dose levels (sometimes 500,000 IU per day) effects such as reduced production of sebum and dry hair could be noticed. However the vitamin also had many other prominent side effects which inhibited its widespread use.
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Accu's Help and Support Site - A weblog of one user's experience with Accutane and links to other resources.
Accutane - Product and prescribing information for US residents in PDF format. [Requires Acrobat Reader]
Anon's Roaccutane Diary - A weekly diary of an Accutane user's description of side effects experienced.
DrugDigest: Isotretinoin - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
Isotretinoin (marketed as Accutane) - Consumer information sheet provided by the U.S. Food and Drug Administration Center for Drug Evaluation and Research. Includes FDA alerts.
Meta Description: [ Isotretinoin (marketed as Accutane) Information ]
Jenn's Accutane Journal - Weekly journal of a girl on this medication including side-effects, results, problems and recommendations.
MedlinePlus: Isotretinoin - Features information about dosage, usage, warnings, and side effects.
Meta Description: [ Isotretinoin ]
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