Irinotecan is a chemotherapy agent that is a topoisomerase 1 inhibitor.
Its main use is in colon cancer, particularly in combination with other chemotherapy agents. This includes the regimen FOLFIRI which consists of infusional 5-fluorouracil, leucovorin, and irinotecan.
Irinotecan is marketed by Pfizer as Camptosar®. It is also known as CPT-11.
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