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Infliximab (Remicade®) is a powerful drug used to treat auto-immune disorders like Crohn's disease and rheumatoid arthritis. Infliximab is known as a "chimeric monoclonal antibody" (the term "chimeric" refers to the use of both mouse and human components of the drug i.e. mouse binding VK and VH domains and human constant Fc domains). The drug reduces the amount of active TNF-α (tumour necrosis factor alpha) in the body by binding to it and preventing it from signaling the receptors for TNF-α on the surface of cells. TNF-α is one of the key cytokines that triggers and sustains the inflammation response. Remicade was invented by Junming Le and Jan Vilcek at New York University School of Medicine and developed by Centocor, a pharmaceutical company owned by Johnson & Johnson.
In the United States, Infliximab is indicated (approved by the US Food and Drug Administration (FDA)) for the treatment of rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, ulcerative colitis, adult Crohn's disease and pediatric Crohn's disease. It is the only anti-TNF alpha biologic in its class with an indication for the latter 3 diseases.
Remicade is administered by intravenous infusion, typically at a clinic or hospital. It cannot be administered orally, because the digestive system would destroy the drug.
More on [ Infliximab ]
Crohn's Disease
Rheumatoid Arthritis
Family Doctor: Ulcerative colitis: Inflammatory bowel ailment: An IV medication called infliximab (also commonly us... http://bit.ly/5lLBXd
barreto57 (Julio Barreto) Wed, 09 Dec 2009 04:01:43 -0000
Family Doctor: Ulcerative colitis: Inflammatory bowel ailment: An IV medication called infliximab (also commonly us... http://bit.ly/5lLBXd
NICE recommends infliximab and adalimumab for the treatment of ... http://bit.ly/6laJGV
ibduk (Crohns Colitis) Mon, 07 Dec 2009 17:17:59 -0000
NICE recommends infliximab and adalimumab for the treatment of ... http://bit.ly/6laJGV
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infliximab (kmatsuoch) Mon, 07 Dec 2009 12:59:25 -0000
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Successful treatment of hidradenitis suppurativa with infliximab in a patient who failed to respond to etanercept http://tinyurl.com/ya9bbl3
hssupport (HS Support) Mon, 07 Dec 2009 11:55:03 -0000
Successful treatment of hidradenitis suppurativa with infliximab in a patient who failed to respond to etanercept http://tinyurl.com/ya9bbl3
infliximab 2 treat crohn's-like inflammatory bowel disease in chronic granulomatous disease http://bit.ly/7hFAvv
paidtrials (US Clinical Trials) Mon, 07 Dec 2009 02:26:59 -0000
infliximab 2 treat crohn's-like inflammatory bowel disease in chronic granulomatous disease http://bit.ly/7hFAvv
Re: starting infliximab / Remicade Diary http://bit.ly/4quatp
skinsmile (skin smile) Mon, 07 Dec 2009 00:31:35 -0000
Re: starting infliximab / Remicade Diary http://bit.ly/4quatp
DrugDigest: Infliximab (Remicade) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Remicade - Details about this drug treatment for Crohn's Disease and rheumatoid arthritis, by Centocor Pharmaceuticals.
The Remicade Letters - CBC: Disclosure - A look at a controversial marketing campaign and the drug company behind it.
Meta Description: [ A look at a controversial marketing campaign and the drug company behind it. ]
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