Hydroxyzine is a piperazine derivative that is used as an antihistamine (especially for itches), anti-emetic (nausea reducing), and anxiolytic (anxiety reducing) drug. It can also be used as an adjunct to pre- and post-operative medication and it also possesses a weak analgesic effect. Hydroxyzine is sold under brand names such as Atarax, Ucerax, Serecid and Vistaril.
Pharmacokinetics
Hydroxyzine can be administered orally as hydroxyzine
hydrochloride or hydroxyzine embonate or as an intramuscular injection as hydroxyzine hydrochloride. When given orally, hydroxyzine is rapidly absorbed from the gastro-intestinal tract. The effect of hydroxyzine is notable in 30 minutes. Hydroxyzine is diffused throughout the body, but higher concentrations can be found in the skin than in the plasma.
It is metabolised in the liver, and the main metabolite (45%), through oxidation of the alcohol moiety to a carboxylic acid, is
cetirizine.
Hydroxyzine's half-life is on average 14 hours for adults, but it can be as low as 5 hours for small children and over 30 hours for elderly people. Hydroxyzine is excreted into the urine almost wholly as metabolites.
Side effects
The
side effects of hydroxyzine are usually mild, and include drowsiness and dry mouth, which is due to slight
anticholinergic action. In rare cases muscle
tremor and
convulsions may occur. Severe somnolence may occur in users with antihistamine sensitivities. Hydroxyzine possesses no addictive potential, unlike benzodiazepines.
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Antihistamines :: Drugs and Medications
Hydroxyzine - Twitter Searchofficially feeling 'loopy' on hydroxyzine and medrol.stacey_cochran (Stacey Cochran) Thu, 05 Nov 2009 19:16:39 -0000
officially feeling 'loopy' on hydroxyzine and medrol.
experiment for the night: 6.5mg zolpidem, 25mg hydroxyzine,10mg diazepamfanyechka (fanyechka) Thu, 05 Nov 2009 15:50:57 -0000
experiment for the night: 6.5mg zolpidem, 25mg hydroxyzine,10mg diazepam
self-experimentation tonight: 25mg hydroxyzine and 10mg diazepam... Would take 20mg but i have a doctor's appt tomorrow morning -_-fanyechka (fanyechka) Wed, 04 Nov 2009 11:57:35 -0000
self-experimentation tonight: 25mg hydroxyzine and 10mg diazepam... Would take 20mg but i have a doctor's appt tomorrow morning -_-
@heatherocity Thats hydroxyzine. Anxiety meds.I_Love_AFI (LindsayRose Springer) Mon, 02 Nov 2009 22:04:12 -0000
@heatherocity Thats hydroxyzine. Anxiety meds.
Iterax Hydroxyzine to help me be less blotchy and more rested. I took a sedative when I have to wake up 30 minutes from now for work.kaikikai (Kyla Cruz) Mon, 02 Nov 2009 19:42:01 -0000
Iterax Hydroxyzine to help me be less blotchy and more rested. I took a sedative when I have to wake up 30 minutes from now for work.
Same as hydroxyzine. Almost like placebo sugar pills. RT @vapourwared: I've given up on using Temazepam, I agree that it's utterly useless.benpolar (benpolar) Sun, 01 Nov 2009 00:21:27 -0000
Same as hydroxyzine. Almost like placebo sugar pills. RT @vapourwared: I've given up on using Temazepam, I agree that it's utterly useless.
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Atarax - Usage, dosage, side effects and interactions.
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Hydroxyzine - MedicineNet article covering usage, dosing, side effects, drug interactions, and related drugs.
Meta Description: [ Specifies the medication hydroxyzine (Vistaril, Atarax), a drug used for the relief of nasal and non-nasal symptoms of various allergic conditions such as seasonal allergic rhinitis. ]
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