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Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation.
Synthesis
Cortisol is synthesized from pregnenolone. The conversion involves hydroxylation of C-11, C-17, and C-21, the oxidation of C-3, and the isomerization of the C-5 double bond to C-4. The synthesis takes place in the zona fasciculata of the cortex of the adrenal glands. While the adrenal cortex also produces aldosterone (in the zona glomerulosa) and some sex hormones (in the zona reticulosa), cortisol is its main secretion. (The name cortisol comes from cortex.) The medulla of the adrenal gland lies under the cortex and mainly secretes epinephrine and norepinephrine under sympathetic stimulation.
The synthesis of cortisol in the adrenal gland is stimulated by the anterior lobe of the pituitary gland with adrenocorticotropic hormone (ACTH); production of ACTH is in turn stimulated by corticotropin-releasing hormone (CRH), released by the hypothalamus.
More on [ Cortisol ]
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Liaandaristaa (Lia Andarista S) Sun, 08 Nov 2009 11:33:17 -0000
di depan mata ada salep bioplacenton sama hydrocortisone yang kemaren kemaren kemarennya malem tak pake
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ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy ... - Journal of Clinical Endocrinology and Metabolism
RidCancer (Rid Cancer) Sat, 07 Nov 2009 22:37:02 -0000
ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy ... - Journal of Clinical Endocrinology and Metabolism
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RidCancer (Rid Cancer) Sat, 07 Nov 2009 20:30:02 -0000
ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy ... - Journal of Clinical Endocrinology and Metabolism http://
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DrugDigest: Hydrocortisone Rectal - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
