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Heparin is a highly sulfated glycosaminoglycan widely used as an injectable anticoagulant. It is also used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines. Pharmaceutical grade heparin is commonly derived from the tissue of slaughter house animals e.g. porcine intestine or bovine lung..
History
Heparin is one of the oldest drugs currently still in widespread clinical use. Its introduction predates the establishment of the United States Food and Drug Administration.. It was originally isolated from liver cells, hence its name (hepar or "ηπαρ" is Greek for "liver"). Scientists were looking for an anticoagulant that could work safely in humans, and Jay McLean, a second-year medical student from Johns Hopkins University working under the guidance of William Henry Howell, found a compound extracted from liver that acted as an anticoagulant.
Medical uses
Heparin acts as an anticoagulant, preventing the formation of clots and extension of existing clots within the blood. While heparin does not break down clots that have already formed, it allows the body's natural clot lysis mechanisms to work normally to break down clots that have already formed. Heparin is used for anticoagulation for the following conditions:
- Acute coronary syndrome, e.g., myocardial infarction
- Atrial fibrillation
- Deep-vein thrombosis and pulmonary embolism.
Blood Coagulation Disorders
Thrombosis :: Vascular Disorders
Took the Heparin. I asked my doc a million questions and we both confirmed this was the smartest move. The needle? Is. Huge. #diabetes
sixuntilme (Kerri | diabetes) Thu, 05 Nov 2009 20:49:55 -0000
Took the Heparin. I asked my doc a million questions and we both confirmed this was the smartest move. The needle? Is. Huge. #diabetes
Idag har jag varit nurse på riktigt: satt en infart, gett heparin, gett antibiotika I infarten jag satte och kuffat en KAD. Nu är jag trött.
ettpalla (Malin) Wed, 04 Nov 2009 21:30:30 -0000
Idag har jag varit nurse på riktigt: satt en infart, gett heparin, gett antibiotika I infarten jag satte och kuffat en KAD. Nu är jag trött.
Which applies to Fibroblasts? A: Ingest dead cells B: Contains Heparin C: Binds adjacent keratinocytes D: ... http://bit.ly/uOcG0
WCEI (WCEI) Wed, 04 Nov 2009 18:40:06 -0000
Which applies to Fibroblasts? A: Ingest dead cells B: Contains Heparin C: Binds adjacent keratinocytes D: ... http://bit.ly/uOcG0
In American Laboratory Magazine: Impurity Evaluation of Heparin Sodium by Anion Exchange Chromatography http://bit.ly/1gcjOF #biotech
WatersUPLC (Waters Division) Wed, 04 Nov 2009 16:31:03 -0000
In American Laboratory Magazine: Impurity Evaluation of Heparin Sodium by Anion Exchange Chromatography http://bit.ly/1gcjOF #biotech
Heparin Ingredients Collected From Unregulated Farms, Fda Claims - Law - http://tinyurl.com/yk92yyz
PrevostDallass (PrevostDallass) Wed, 04 Nov 2009 08:05:50 -0000
Heparin Ingredients Collected From Unregulated Farms, Fda Claims - Law - http://tinyurl.com/yk92yyz
Heparin can do crazy things. Eek.
erin_kane (Erin Kane) Wed, 04 Nov 2009 06:45:00 -0000
Heparin can do crazy things. Eek.
Antithrombotics - Heparin - Information and resources about the drug from KU-W MedEd Online.
Celsus - Manufacturer of heparin and heparin-like glycosaminoglycans including Centaxarin (ardeparin sodium). Features scientific background and history.
Meta Description: [ A GMP-Manufacturer of heparin and other glycosaminoglycans. Celsus Laboratories is a USDA-approved, FDA-audited drug establishment with the capacity to manufacture and test GAGs. ]
Centaxarin - Ardeparin sodium. Features history and chemical data.
Meta Description: [ A GMP-Manufacturer of heparin and other glycosaminoglycans. Celsus Laboratories is a USDA-approved, FDA-audited drug establishment with the capacity to manufacture and test GAGs. ]
DrugDigest: Heparin - Information on dosage, usage, side effects, interactions, and drug comparisons for the low molecular weight form of the drug.
Heparins in the New Millennium: Will Unfractionated Heparin Survive? - A comprehensive discussion of the history and future of unfractionated heparin versus low molecular weight heparins. [Requires free Medscape membership]
Innohep - Prescribing information for US residents in PDF format. [Acrobat Reader required]
Innohep - Tinzaparin sodium. Features product information as well as descriptions of deep vein thrombosis and pulmonary embolisms.
Meta Description: [ LEO Pharma ]
Low Molecular Weight Heparins - Questions and answers from the Food and Drug Administration.
Low Molecular Weight Heparins in Medicine and Anaesthesia - Compares LMW and unfractionated heparins and offers information, uses, study results, and recommendations.
Venous Thromboembolism and Low-Molecular-Weight Heparins: New Treatment Options - Discussion of the uses of LMW heparins in the treatment of thromboembolic events.
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