Guanfacine is a centrally acting antihypertensive agent. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α-2 adrenergic receptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.

Generic Status

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Guanfacine is the generic name for the drug Tenex.

Side effects

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Usual: Dizziness, drowsiness, headache, constipation, gas pains, diarrhea, loss of appetite, fatigue, and nasal congestion may occur.

Rare: chest pain, shortness of breath, skin rash, swelling of the hands or feet, blurred vision, yellowing of the eyes or skin.

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