Gonadotropin-releasing hormone 1 (GNRH1) is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GNRH1 is synthesized and released by the hypothalamus.

Gene

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The gene, GNRH1, for the GNRH1 precursor is located on chromosome 8. This precursor contains 92 amino acids and is processed to GNRH1, a decapeptide (10 amino acids) in mammals. This chain is represented by: pGlu-His-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Structure

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The identity of GNRH1 was clarified by the 1977 Nobel Laureates Roger Guillemin and Andrew V. Schally:

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