Glycopyrrolate is a medication of the muscarinic anticholinergic group. It is a synthetic quaternary amine with no central effects and is available in oral and intraveinous (i.v.) forms, although oral absorption is less than 5%.
In anesthesia, glycopyrrolate injection can be used as a preoperative medication on order to reduce salivary, tracheobronchial, and pharyngeal secretions, as well as decreasing the acidity of gastric secretion. It is also used in conjunction with neostigmine, a neuromuscular blocking reversal agent, to prevent neostigmine's muscarinic effects such as bradycardia.
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