Gourt > Health > Pharmacy > Drugs and Medications > G > Glipizide
Glipizide is an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation Sulfonylurea, which means that it undergoes enterohepatic circulation. The structure on the R2 group is a much larger cyclo or aromatic group compared to the 1st generation sulfonylureas. This leads to a once a day dosing that is much less then the first generation, about 100 fold. Mechanism of action is produced by blocking potassium K+ channels in the Beta cells of the Islets of Langerhans. By partially blocking the K+ channels, you will increase the time the cell spends in the Calcium release stage of cell signaling leading to an increase in calcium. The increase in Calcium will initiate more Insulin release from each Beta cell.
It is available under the brand name Glucotrol® by Pfizer, originally available in 1984. Pfizer sells Glucotrol in doses of 5 and 10 milligrams and Glucotrol XL (an extended release form of glipizide) in doses of 2.5, 5, and 10 milligrams. Other companies sell generic forms of glipizide, most commonly extended release tablets of 5 and 10 milligrams.
External links
- Glucotrol XL Full U.S. Prescribing Information. Accessed on July 26, 2005.
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
_clinical_trial (Clinical Trials) Mon, 21 Dec 2009 06:42:40 -0000
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
ustrials (US Trials) Mon, 21 Dec 2009 06:14:39 -0000
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
newtrials_ (New Clinical Trials) Mon, 21 Dec 2009 06:10:40 -0000
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
goclinicaltrial (Clinical Trials) Mon, 21 Dec 2009 06:10:39 -0000
sitagliptin vs glipizide in ppl w/ type 2 diabtes mellitus & end-stage renal disease http://bit.ly/5N4Usa
@EndoGoddess yep. he started on avandia and glipizide, then got TID NPH. used the freestyle meter on his ear to do glucose curves.
DrElena (Elena A Christofides) Thu, 17 Dec 2009 03:21:49 -0000
@EndoGoddess yep. he started on avandia and glipizide, then got TID NPH. used the freestyle meter on his ear to do glucose curves.
DrugDigest: Glipizide ( Glucotrol ) - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
