.png | width = 200 | image2 = gemzar_logo.gif | CAS_number = 103882-84-4 | ATC_prefix = L01 | ATC_suffix = BC05 | ATC_supplemental = | PubChem = 60750 | DrugBank = APRD00201 | chemical_formula = C₉H₁₁F₂N₃O₄ | molecular_weight = 263.198 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = Oral, intravenous }} Gemcitabine is a nucleoside used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company.

Chemistry

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Chemically gemcitabine is a nucleoside in which the hydrogens on the 2' carbon of deoxycytidine are replaced by fluorides.

Mode of action

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As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis (cellular "suicide").

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Gemcitabine - Twitter Search

Gemcitabine-induced radiation recall dermatitis following whole... http://tinyurl.com/yf7n5yx
melin089 (Melinda Peck) Sun, 08 Nov 2009 05:47:09 -0000
Gemcitabine-induced radiation recall dermatitis following whole... http://tinyurl.com/yf7n5yx
@DorisJPhillips Next Friday I will get Gemcitabine and Taxotere - http://www.chemocare.com/bio/taxotere.asp
kayfturner (Kay Turner) Fri, 06 Nov 2009 20:54:19 -0000
@DorisJPhillips Next Friday I will get Gemcitabine and Taxotere - http://www.chemocare.com/bio/taxotere.asp
@DorisJPhillips Today I got Gemcitabine: http://www.chemocare.com/bio/gemcitabine.asp.
kayfturner (Kay Turner) Fri, 06 Nov 2009 20:52:42 -0000
@DorisJPhillips Today I got Gemcitabine: http://www.chemocare.com/bio/gemcitabine.asp.
Radiology publications: Randomized Phase III Trial of Gemcitabine-Based Chemotherapy With I... http://bit.ly/25Uhwb
Radiology_help (Radiology help) Fri, 06 Nov 2009 20:49:53 -0000
Radiology publications: Randomized Phase III Trial of Gemcitabine-Based Chemotherapy With I... http://bit.ly/25Uhwb
Weekly combo gemcitabine+topotecan produces 14% ORR in plat.-resist. OVCA pts., but 60% w/stable disease & symptom ctr. http://is.gd/4P2YW
libbyshope (Paul Cacciatore) Fri, 06 Nov 2009 19:31:25 -0000
Weekly combo gemcitabine+topotecan produces 14% ORR in plat.-resist. OVCA pts., but 60% w/stable disease & symptom ctr. http://is.gd/4P2YW
Peds: Treatment of Relapsed/Refractory Pediatric Sarcomas With Gemcitabine and Docetaxel: Journal of Pediatric Hematolog http://url4.eu/hkB8
MDLinx (Sandeep Pulim MD) Fri, 06 Nov 2009 10:02:20 -0000
Peds: Treatment of Relapsed/Refractory Pediatric Sarcomas With Gemcitabine and Docetaxel: Journal of Pediatric Hematolog http://url4.eu/hkB8

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