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.png | width = 200 | image2 = gemzar_logo.gif | CAS_number = 103882-84-4 | ATC_prefix = L01 | ATC_suffix = BC05 | ATC_supplemental = | PubChem = 60750 | DrugBank = APRD00201 | chemical_formula = C9H11F2N3O4 | molecular_weight = 263.198 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = Oral, intravenous }} Gemcitabine is a nucleoside used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company.

Chemistry


Chemically gemcitabine is a nucleoside in which the hydrogens on the 2' carbon of deoxycytidine are replaced by fluorides.

Mode of action


As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis (cellular "suicide").

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Gencitabine ( Gemzar ) from Eli Lilly - Medicine and oncology resources designed to help patients in discussions with health care professionals about chemotherapy and treatment with Gemzar.

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