.png | width = 200 | image2 = gemzar_logo.gif | CAS_number = 103882-84-4 | ATC_prefix = L01 | ATC_suffix = BC05 | ATC_supplemental = | PubChem = 60750 | DrugBank = APRD00201 | chemical_formula = C9H11F2N3O4 | molecular_weight = 263.198 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = Oral, intravenous }}
Gemcitabine is a nucleoside used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company.
Chemistry
Chemically gemcitabine is a
nucleoside in which the hydrogens on the 2' carbon of
deoxycytidine are replaced by
fluorides.
Mode of action
As with
fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case
cytidine, during
DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in
apoptosis (cellular "suicide").
More on
[ Gemcitabine ]
Gemcitabine - Twitter Searchcapecitabine, cyclophosphamide, doxorubicin, gemcitabine, lapatinib, paclitaxel, trastuzumab, or vinorelbine in http://bit.ly/5Ggdmkusclinicaltrial (US Clinical Trials) Fri, 18 Dec 2009 17:58:53 -0000
capecitabine, cyclophosphamide, doxorubicin, gemcitabine, lapatinib, paclitaxel, trastuzumab, or vinorelbine in http://bit.ly/5Ggdmk
gemcitabine and/or erlotinib as 1st-line thrpy in treating older ppl w/ stage iiib or stage iv non-small cell lung http://bit.ly/7AQQixustrials (US Trials) Fri, 18 Dec 2009 14:26:49 -0000
gemcitabine and/or erlotinib as 1st-line thrpy in treating older ppl w/ stage iiib or stage iv non-small cell lung http://bit.ly/7AQQix
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UNustrials (US Trials) Fri, 18 Dec 2009 11:50:48 -0000
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UN
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UNgoclinicaltrial (Clinical Trials) Fri, 18 Dec 2009 11:50:41 -0000
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UN
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UN_clinical_trial (Clinical Trials) Fri, 18 Dec 2009 11:46:46 -0000
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UN
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UNnewtrials_ (New Clinical Trials) Fri, 18 Dec 2009 11:30:50 -0000
dose escalation arq 197 in combo w/ gemcitabine in adult ppl w/ advanced solid tumors http://bit.ly/5FQ9UN
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Gencitabine ( Gemzar ) from Eli Lilly - Medicine and oncology resources designed to help patients in discussions with health care professionals about chemotherapy and treatment with Gemzar.