.png | width = 200 | image2 = gemzar_logo.gif | CAS_number = 103882-84-4 | ATC_prefix = L01 | ATC_suffix = BC05 | ATC_supplemental = | PubChem = 60750 | DrugBank = APRD00201 | chemical_formula = C₉H₁₁F₂N₃O₄ | molecular_weight = 263.198 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = Oral, intravenous }} Gemcitabine is a nucleoside used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company.

Chemistry

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Chemically gemcitabine is a nucleoside in which the hydrogens on the 2' carbon of deoxycytidine are replaced by fluorides.

Mode of action

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As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis (cellular "suicide").

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