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Ganciclovir (INN) (IPA: ) is an antiviral medication used to treat or prevent cytomegalovirus (CMV) infections. It was developed by Canadian scientist Kelvin K. Ogilvie.Ogilvie KK. Biography – Kelvin K. Ogilvie Wolfville (NS): Acadia University; c2003. [updated 2003 Sep 17; cited 2006 May 28. Available from: http://ace.acadiau.ca/science/chem/faculty/kko/Biography.html Ganciclovir sodium is marketed under the trade names Cytovene and Cymevene (Roche). Ganciclovir for ocular use is marketed under the trade name Vitrasert (Bausch & Lomb). A prodrug form with improved oral bioavailability (valganciclovir) has also been developed.
Mechanism of action
Ganciclovir is a synthetic analogue of 2'-deoxy-guanosine. It is first phosphorylated to a deoxyguanosine triphosphate (dGTP) analog. This competitively inhibits the incorporation of dGTP by viral DNA polymerase, resulting in the termination of elongation of viral DNA.
Clinical use
Indications
Ganciclovir is indicated for:Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN 0-9757919-2-3- Sight-threatening CMV retinitis in severely immunocompromised people
- CMV pneumonitis in bone marrow transplant recipients
- Prevention of CMV disease in bone marrow and solid organ transplant recipients
- Confirmed CMV retinitis in people with AIDS (intravitreal implant)
http://t.co/qt9QpaVc Polymerase Chain ReactionâBased Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology
heatgardtiger (Heather Gardner) Sat, 21 Jan 2012 18:52:30 -0000
http://t.co/qt9QpaVc Polymerase Chain Reaction–Based Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology
Polymerase Chain ReactionâBased Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology
PalfourGift (Madalyn Delgado) Sat, 21 Jan 2012 05:13:42 -0000
Polymerase Chain Reaction–Based Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology
http://t.co/H5MoRtP2 ganciclovir (ганÑикловиÑ)
osamoha (СеÑгей Ð¡Ð°Ð¼Ð¾Ñ a) Fri, 20 Jan 2012 21:20:49 -0000
http://t.co/H5MoRtP2 ganciclovir (ганцикловир)
A farmácia da Ure Dipe continua sem medicamentos básicos ao tratamento contra o HIV: Ganciclovir 500mg, Dexametazona creme,
harechris (Maria Christina) Fri, 20 Jan 2012 18:41:14 -0000
A farmácia da Ure Dipe continua sem medicamentos básicos ao tratamento contra o HIV: Ganciclovir 500mg, Dexametazona creme,
Polymerase Chain ReactionâBased Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology http://t.co/IBDD5W53
VioOkaone (Violet Okamoto) Fri, 20 Jan 2012 15:03:34 -0000
Polymerase Chain Reaction–Based Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology http://t.co/IBDD5W53
Polymerase Chain ReactionâBased Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology http://t.co/IBDD5W53
VioOkaone (Violet Okamoto) Fri, 20 Jan 2012 09:41:19 -0000
Polymerase Chain Reaction–Based Ganciclovir Resistance Testing of Ocular ... - Archives of Ophthalmology http://t.co/IBDD5W53
DrugDigest: Ganciclovir - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
Ganciclovir - a.k.a. DHPG, Cytovene.
Ganciclovir - A treatment for CMV (cytomegalovirus) infection.(Cytovene, DHPG)
Ganciclovir implants - A special implant that is put directly into an infected eye.(Vitrasert)
