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Gabapentin (brand name: Neurontin®) was initially synthesized to mimic the structure of GABA for the treatment of epilepsy. Nowadays, gabapentin has been widely used as a medication to relieve pain, especially neuropathic pain. Gabapentin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized.

Gabapentin is similar in structure to the neurotransmitter GABA but is not believed to act on the same brain receptors. Its exact mechanism of action is unknown, but its therapeutic action on neuropathic pain is thought to involve voltage-gated calcium ion channels.

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Gabapentin was originally approved by the FDA as an antiseizure medication. It is not effective for patients with absence seizures.

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DrugDigest: Gabapentin ( Neurontin ) - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.

Neurontin - Anticonvulsant agent. Prescribing information for US residents in PDF format. [Acrobat Reader required]

Public Citizen: Neurontin (Gabapentin) - Alleges that the drug's manufacturer fabricated data supporting the off-label use of the anti-seizure medication for other neurological and psychiatric disorders.

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