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Fulvestrant, also known as ICI 182,780, is a drug treatment of hormone receptor positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.S. Kansra, S. Yamagata, L. Sneade, L. Foster & N. Ben-Jonathan, 2005. "Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release." Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36. It is administered as a once-monthly injection.
Fulvestrant is marketed by AstraZeneca with the brand name Faslodex.
References
Cancer: Fulvestrant (Faslodex ) Mechanism of Action. http://t.co/KGdFE7VD
SymPathoBiology (Sympo PathoBiology) Thu, 26 Jan 2012 21:58:40 -0000
Cancer: Fulvestrant (Faslodex ) Mechanism of Action. http://t.co/KGdFE7VD
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nsklaghouat (Ness El khir laghoua) Thu, 26 Jan 2012 13:25:50 -0000
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500
Faslodex - AstraZeneca - Provides medication information for patients and U.S. healthcare professionals
Faslodex Consumer Information - FDA - Patient FAQ in html format with a link to approved labeling in pdf format.
Fulvestrant - FamilyDoctor.org - Information for patients in English or Spanish.
