Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. In the ovary FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin, which shuts off the FSH production.
In men, FSH enhances the production of androgen-binding protein by the Sertoli cells of the testes and is critical for spermatogenesis. FSH and LH act synergistically in reproduction.
Structure
FSH is a
glycoprotein. Each monomeric unit is a protein molecule with a sugar attached to it; two of these make the full, functional protein. Its structure is similar to
LH,
TSH, and
hCG. The protein dimer contains 2
polypeptide units, labelled alpha and beta subunits. The
alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92
amino acids. The beta subunits vary. FSH has a beta subunit of 118 amino acids (FSHB) that confers its specific biologic action and is responsible for interaction with the
FSH-receptor.The sugar part of the hormone is composed of
fructose,
galactose,
mannose,
galactosamine,
glucosamine, and
sialic acid, the latter being critical for its biologic
half-life. The half-life of FSH is 3-4 hours.
Genes
The gene for the
alpha subunit is located on chromosome 6p21.1-23. It is expressed in different cell types. The gene for the FSH beta subunit is located on chromosome 11p13 and is expressed in gonadotropes of the pituitary cells, controlled by
GnRH, inhibited by
inhibin, and enhanced by
activin.
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