Fluphenazine is a typical antipsychotic drug used for the treatment of psychoses such as schizophrenia and acute manic phases of bipolar depression. It belongs to the piperazine class of phenothiazines and is extremely potent; more potent than haloperidol and around fifty to seventy times the potency of chlorpromazine.

Brand names

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Fluphenazine decanoate	Modecate®, Prolixin Decanoate®, Dapotum D®, Anatensol®, Fludecate®, Sinqualone Deconoate®
Fluphenazine enanthate	Dapotum Injektion®, Flunanthate®, Moditen Enanthate Injection®, Sinqualone Enanthate®
Fluphenazine hydrochloride	Prolixin®, Permitil®, Dapotum®, Lyogen®, Moditen®, Omca®, Sediten®, Selecten®, Sevinol®, Sinqualone®, Trancin®

Pharmacokinetics

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Fluphenazine has an incomplete oral bioavailability of 40% to 50% (due to extensive first pass metabolization in the liver). Its half life is 15 to 30 hours.

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