Fluconazole (INN) (IPA: ) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. It is commonly marketed under the trade name Diflucan (Pfizer).

Pharmacology

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Mode of action

Like other imidazole- and triazole-class antifungals, fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cell wall, and subsequent accumulation of 14α-methyl sterols.Pfizer Australia Pty Ltd. Diflucan (Australian Approved Product Information). West Ryde (NSW): Pfizer Australia; 2004. Fluconazole is primarily fungistatic, however may be fungicidal against certain organisms in a dose-dependent manner.

Microbiology

Fluconazole is active against the following microorganisms:Sweetman S, editor. Martindale: The complete drug reference. 34th ed. London: Pharmaceutical Press; 2004. ISBN 0-8536955-0-4

• Blastomyces dermatitidis
• Candida spp. (except C. krusei and C. glabrata)
• Coccidioides immitis
• Cryptococcus neoformans
• Epidermophyton spp.
• Histoplasma capsulatum
• Microsporum spp.
• Trichophyton spp.

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Fluconazole - Twitter Search

attn: if you have ever taken the following: fluconazole, valtrex, tetracycline, levaquin, and or zovirax @KinoINTL is waiting for ya
elldacycoeABS (Ellison McKnight) Sat, 02 Jan 2010 19:04:05 -0000
attn: if you have ever taken the following: fluconazole, valtrex, tetracycline, levaquin, and or zovirax @KinoINTL is waiting for ya
Balanitis Fluconazole http://bit.ly/4IuDsG
YeastHoncho (Thery Zavala) Sat, 02 Jan 2010 17:46:59 -0000
Balanitis Fluconazole http://bit.ly/4IuDsG
Free P&P see T&C's #2: Care Fluconazole Capsule Single: Care Fluconazole Capsule Single by Ca.. http://bit.ly/88usAp
bestshopinuk (Best Shop in the UK) Fri, 01 Jan 2010 20:55:30 -0000
Free P&P see T&C's #2: Care Fluconazole Capsule Single: Care Fluconazole Capsule Single by Ca.. http://bit.ly/88usAp
On the other hand, no more fluconazole if it's -azole resistant candidia.
alumiere (alumiere) Fri, 01 Jan 2010 01:27:01 -0000
On the other hand, no more fluconazole if it's -azole resistant candidia.
feel like they're tapped at the point where the esophagus meets stomach. So I must stop taking fluconazole now. Candidia will get worse tho
alumiere (alumiere) Thu, 31 Dec 2009 04:36:15 -0000
feel like they're tapped at the point where the esophagus meets stomach. So I must stop taking fluconazole now. Candidia will get worse tho
FLUCONAZOLE [WEB COMMENTARY] Use Pharmacology Diagnosing systemic ... http://bit.ly/7b45GC
YeastHoncho (Thery Zavala) Tue, 29 Dec 2009 23:40:04 -0000
FLUCONAZOLE [WEB COMMENTARY] Use Pharmacology Diagnosing systemic ... http://bit.ly/7b45GC

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