Fluconazole (INN) (IPA: ) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. It is commonly marketed under the trade name Diflucan (Pfizer).

Pharmacology

---

Mode of action

Like other imidazole- and triazole-class antifungals, fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cell wall, and subsequent accumulation of 14α-methyl sterols.Pfizer Australia Pty Ltd. Diflucan (Australian Approved Product Information). West Ryde (NSW): Pfizer Australia; 2004. Fluconazole is primarily fungistatic, however may be fungicidal against certain organisms in a dose-dependent manner.

Microbiology

Fluconazole is active against the following microorganisms:Sweetman S, editor. Martindale: The complete drug reference. 34th ed. London: Pharmaceutical Press; 2004. ISBN 0-8536955-0-4

• Blastomyces dermatitidis
• Candida spp. (except C. krusei and C. glabrata)
• Coccidioides immitis
• Cryptococcus neoformans
• Epidermophyton spp.
• Histoplasma capsulatum
• Microsporum spp.
• Trichophyton spp.

More on [ Fluconazole ]

Fluconazole - Twitter Search

Categories: Facts Tags: fluconazole, form, lozenges, medication, oral, pills, suspension, treatment
lillieLane2543 (lillie Lane) Sat, 31 Dec 2011 23:43:56 -0000
Categories: Facts Tags: fluconazole, form, lozenges, medication, oral, pills, suspension, treatment
Fluconazole Tablets Diflucan 100mg - European doctors and #accutane at http://t.co/r0eLUhde! => http://t.co/i4Pu2bpZ
yfequsobu (Jabe Acoff) Sat, 31 Dec 2011 23:37:03 -0000
Fluconazole Tablets Diflucan 100mg - European doctors and #accutane at http://t.co/r0eLUhde! =a href="http://t.co/i4Pu2bpZ"/a<
#diflucan: Ciprofloxacin HCl Tablets: Generic Cipro - Fluconazole risk in pregnan Subscribe to Fluconazole RSS feed