Ezetimibe (IPA: ) is an anti-hyperlipidemic medication which is used to lower cholesterol levels. It acts by decreasing cholesterol absorption in the intestine. It may be used alone when other cholesterol-lowering medications are unable to be tolerated, or together with statins (e.g. ezetimibe/simvastatin) when cholesterol levels are unable to be controlled on statins alone. It is marketed by Schering-Plough and Merck under the trade names Ezetrol, Zetia and Ezemibe.

Pharmacology

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Ezetimibe localises at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the diet. Specifically, it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium, a critical mediator of cholesterol absorption.Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, et al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc Natl Acad Sci U S A 2005;102(23):8132-7. PMID 15928087 In addition to this direct effect, decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells, thus decreasing levels in the blood plasma.

Clinical use

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Indications

Ezetimibe is indicated as an adjunct to dietary measures in the management of:

• Hypercholesterolaemia
• Homozygous sitosterolaemia (phytosterolaemia)Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN 0-9757919-2-3

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Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/46Rfiv
mysitefeed (mysitefeed) Sat, 07 Nov 2009 04:02:32 -0000
Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/46Rfiv
Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/3Cikjd
mysitefeed (mysitefeed) Sat, 07 Nov 2009 03:02:30 -0000
Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/3Cikjd
Vytorin lowers cholesterol in 2 ways statin blocks the body's production in the body ezetimibe reduces amount absorbed by the intestines #FB
mrcmv (charles varner) Fri, 06 Nov 2009 16:09:09 -0000
Vytorin lowers cholesterol in 2 ways statin blocks the body's production in the body ezetimibe reduces amount absorbed by the intestines #FB
EDS: Ezetimibe/simvastatin: Expert Opinion on Drug Safety , November 2009, Vol. 8, No. 6, Pages 715-725. http://bit.ly/4ukGJS
ExpertOpinion (Expert Opinion) Fri, 06 Nov 2009 13:37:28 -0000
EDS: Ezetimibe/simvastatin: Expert Opinion on Drug Safety , November 2009, Vol. 8, No. 6, Pages 715-725. http://bit.ly/4ukGJS
If this is being caused by a statin, I'd feel better about taking him off the statin and starting ezetimibe. #advdm691
caderj (Robert Cade) Thu, 05 Nov 2009 20:41:17 -0000
If this is being caused by a statin, I'd feel better about taking him off the statin and starting ezetimibe. #advdm691
Heart valve changes don't always warrant treatment: The tempest over ezetimibe arose with the combination d.. http://bit.ly/IAjPm
MedicalNewsUSA (Medical News) Wed, 04 Nov 2009 05:38:58 -0000
Heart valve changes don't always warrant treatment: The tempest over ezetimibe arose with the combination d.. http://bit.ly/IAjPm

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