.jpg | CAS_number = 33419-42-0 | ATC_prefix = L01 | ATC_suffix = CB01 | ATC_supplemental = | PubChem = 36462 | DrugBank = APRD00239 | chemical_formula = C₂₉H₃₂O₁₃ | molecular_weight = 588.557 g/mol | bioavailability = | protein_bound = 97% | metabolism = | elimination_half-life = oral: 6 h., iv: 6-12 h., iv in children: 3 h. | pregnancy_category = | legal_status = | routes_of_administration = Oral, intravenous | excretion = Renal and faeces }} Etoposide phosphate (Eposin®, Etopophos®, Vepesid®, VP-16®) is an inhibitor of the enzyme topoisomerase II. It is used as a form of chemotherapy for malignancies such as lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. It is often given in combination with other drugs.

Chemically it derives from podophyllotoxin, a toxin found in the American Mayapple.

It is given intravenously or by mouth in capsule form. If the drug is given by IV it must be done slowly over a 30 to 60 minute period because it can lower blood pressure as it is being administered. Blood pressure is checked often during infusing. The physician may lengthen or shorten the time depending on circumstances.

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ASCO #GU12 Refractory NSGCT: Induction TIP or TI followed by 2-3 cycles High Dose Chemo (Carbo/Etoposide) followed by Autologous SCT
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ASCO #GU12 Refractory NSGCT: Induction TIP or TI followed by 2-3 cycles High Dose Chemo (Carbo/Etoposide) followed by Autologous SCT

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