Etanercept is a recombinant human soluble tumor necrosis factor-alpha (TNFα) receptor. It is is a small protein, with a molecular weight of 75 kDa (p75), that binds to TNFα and decreases its role in inflammatory diseases such as rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, and ankylosing spondylitis. It is co-marketed by Amgen and Wyeth under the trade name Enbrel.

Development

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Etanercept was developed by researchers at biotechnology company Immunex, which was subsequently purchased by Amgen. It was released in 1999, soon after the release of infliximab (Remicade) – the first chimeric monoclonal antibody against TNFα to be marketed for clinical use.

Mode of action

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Tumor necrosis factor-alpha (TNFα) is a cytokine produced by monocytes and macrophages, two types of white blood cells. It mediates the immune response by increasing the transport of white blood cells to sites of inflammation. Inhibition of its action by etanercept reduces the inflammatory response which is especially useful for treating autoimmune diseases.

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iMedPub (Medical Publishing) Fri, 06 Nov 2009 21:32:08 -0000
I just published etanercept to Scribd http://bit.ly/ptUZe
Quick pain relief, spinal stenosis: The patient responds to a single dose periespinal etanercept within ten mi.. http://bit.ly/4nVxzr
tajazmina (Tannere Jazmina) Thu, 05 Nov 2009 17:57:15 -0000
Quick pain relief, spinal stenosis: The patient responds to a single dose periespinal etanercept within ten mi.. http://bit.ly/4nVxzr
Treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling http://bit.ly/1E3ssJ
Allergy (Ves Dimov, M.D.) Thu, 05 Nov 2009 15:49:45 -0000
Treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling http://bit.ly/1E3ssJ
Quick pain relief, spinal stenosis: The patient responds to a single dose periespinal etanercept within ten mi.. http://bit.ly/30Jlpz
tajazmina (Tannere Jazmina) Thu, 05 Nov 2009 14:10:03 -0000
Quick pain relief, spinal stenosis: The patient responds to a single dose periespinal etanercept within ten mi.. http://bit.ly/30Jlpz
algumas drogas parecem ter sido batizadas por george lucas: anakinra, abatacept, rituximab, etanercept, infliximab, adalimumab, abciximab...
tat_can (tatiane cantarelli) Wed, 04 Nov 2009 00:48:34 -0000
algumas drogas parecem ter sido batizadas por george lucas: anakinra, abatacept, rituximab, etanercept, infliximab, adalimumab, abciximab...
#infliximab and #adalimumab are associated with a 3 to 4-fold higher rate of #tuberculosis compared to #etanercept
shilpanangali (Shilpa Nangali) Mon, 02 Nov 2009 13:40:34 -0000
#infliximab and #adalimumab are associated with a 3 to 4-fold higher rate of #tuberculosis compared to #etanercept

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