Etanercept is a recombinant human soluble tumor necrosis factor-alpha (TNFα) receptor. It is is a small protein, with a molecular weight of 75 kDa (p75), that binds to TNFα and decreases its role in inflammatory diseases such as rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, and ankylosing spondylitis. It is co-marketed by Amgen and Wyeth under the trade name Enbrel.

Development

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Etanercept was developed by researchers at biotechnology company Immunex, which was subsequently purchased by Amgen. It was released in 1999, soon after the release of infliximab (Remicade) – the first chimeric monoclonal antibody against TNFα to be marketed for clinical use.

Mode of action

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Tumor necrosis factor-alpha (TNFα) is a cytokine produced by monocytes and macrophages, two types of white blood cells. It mediates the immune response by increasing the transport of white blood cells to sites of inflammation. Inhibition of its action by etanercept reduces the inflammatory response which is especially useful for treating autoimmune diseases.

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[VEGF] Changes in plasma IL-6, plasma VEGF and serum YKL-40 during Treatment with Etanercept and Metho.. http://bit.ly/8n92qK PM
VEGFRSSfeeds (VEGF RSS Feeds) Thu, 24 Dec 2009 11:27:17 -0000
[VEGF] Changes in plasma IL-6, plasma VEGF and serum YKL-40 during Treatment with Etanercept and Metho.. http://bit.ly/8n92qK PM
efficacy & safety of adding methotrex8 2 etanercept in psoriasis http://bit.ly/8dwH6L
_clinical_trial (Clinical Trials) Thu, 24 Dec 2009 05:14:34 -0000
efficacy & safety of adding methotrex8 2 etanercept in psoriasis http://bit.ly/8dwH6L
etanercept in treating young ppl w/ idiopathic pneumonia syndrome after undergoing donor stem cell transplant http://bit.ly/7NK5lZ
_clinical_trial (Clinical Trials) Wed, 23 Dec 2009 03:58:33 -0000
etanercept in treating young ppl w/ idiopathic pneumonia syndrome after undergoing donor stem cell transplant http://bit.ly/7NK5lZ
etanercept in treating young ppl w/ idiopathic pneumonia syndrome after undergoing donor stem cell transplant http://bit.ly/7NK5lZ
ustrials (US Trials) Wed, 23 Dec 2009 03:30:34 -0000
etanercept in treating young ppl w/ idiopathic pneumonia syndrome after undergoing donor stem cell transplant http://bit.ly/7NK5lZ
etanercept in treating young ppl w/ idiopathic pneumonia syndrome after undergoing donor stem cell transplant http://bit.ly/7NK5lZ
newtrials_ (New Clinical Trials) Wed, 23 Dec 2009 03:26:36 -0000
etanercept in treating young ppl w/ idiopathic pneumonia syndrome after undergoing donor stem cell transplant http://bit.ly/7NK5lZ
Posttraumatic psoriatic osteitis of the frontal bone successfully treated with etanercept. Report of a case http://kele.es/pZU
Sciencia (Webmaster Sciencia) Tue, 22 Dec 2009 09:00:55 -0000
Posttraumatic psoriatic osteitis of the frontal bone successfully treated with etanercept. Report of a case http://kele.es/pZU

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