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Estradiol (17β-estradiol) (also oestradiol) is a sex hormone. Labelled the "female" hormone but also present in males it represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including bone structure.

Synthesis


Estradiol, like other sex steroids, is derived from cholesterol. After side chain cleavage and utilizing the delta-5 pathway or the delta-4 pathway androstenedione is the key intermediary. Androstendione is either converted to testosterone which in turn undergoes aromatization to estradiol, or, alternatively, androstendione is aromatized to estrone which is converted to estradiol.

Production


During the reproductive years most estradiol in women is produced by the granulosa cells of the ovaries by aromatization of testosterone from the theca cells, or conversion of estrone to estradiol. Smaller amounts of estradiol are also produced by the adrenal cortex. In men, the testes produce estradiol.

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Shivaree - Someday... pra uma sexta feira entupida de estradiol
BichoMagro (Luiz Ricardo) Fri, 18 Dec 2009 17:54:30 -0000
Shivaree - Someday... pra uma sexta feira entupida de estradiol
@CRYIZTAL Hola! una de tus amigas creo que trae bajo el estradiol, jeje
DrSonico (Jorge Carrillo) Thu, 17 Dec 2009 23:36:49 -0000
@CRYIZTAL Hola! una de tus amigas creo que trae bajo el estradiol, jeje
Fuckin drodpirenone & ethinyl estradiol. Makes me cry.
laura_lovsky (laura) Thu, 17 Dec 2009 01:04:39 -0000
Fuckin drodpirenone & ethinyl estradiol. Makes me cry.
Estradiol, the most potent estrogen produced by the follicle, stimulates development of the endometrial lining and cervical mucous.
fertilitywire (FertilityWire) Wed, 16 Dec 2009 20:51:26 -0000
Estradiol, the most potent estrogen produced by the follicle, stimulates development of the endometrial lining and cervical mucous.
Estradiol in pediatric endocrinology. - http://bit.ly/7iICJw
ALLeukemiaChild (ALL Leukemia CHild) Wed, 16 Dec 2009 11:26:24 -0000
Estradiol in pediatric endocrinology. - http://bit.ly/7iICJw
@alissiarosepait Been on 3mg estradiol & 200mg spironolactone, now 4mg E & no spiro until further notice. #neveradullmoment
ImpracticalCat (Zoey P.) Wed, 16 Dec 2009 08:37:38 -0000
@alissiarosepait Been on 3mg estradiol & 200mg spironolactone, now 4mg E & no spiro until further notice. #neveradullmoment

 
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