Erythromycin is a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Structurally, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desoamine), making it a compound very difficult to produce via synthetic methods.

Erythromycin is produced from a strain of the actinomyces Saccaropolyspora erythraea, formerly known as Streptomyces erythraeus.

History

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Abelardo Aguilar, a Filipino scientist, sent some soil samples to his employer Eli Lilly in 1949. Eli Lilly’s research team, led by J. M. McGuire, managed to isolate Erythromycin from the metabolic products of a strain of Streptomyces erythreus (designation changed to "Saccharopolyspora erythraea") found in the samples. Lilly filed for patent protection of the compound and U.S. patent 2,653,899 was granted in 1953. The product was launched commercially in 1952 under the brand name Ilosone® (after the Philippine region of Iloilo where it was originally collected from). Erythromycin was formerly also called Ilotycin®. In 1981, Nobel laurate (1965 in chemistry) and Professor of Chemistry at Harvard University (Cambridge, MA) Robert B. Woodward and a large team of researchers reported the first stereocontrolled asymmetric chemical synthesis of Erythromycin A.

The antiobiotic clarithromycin was invented by scientists at the Japanese drug company Taisho Pharmaceutical in the 1970s as a result of their efforts to overcome the acid instability of erythromycin.

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@1capplegate lookin like a hordeolum (Stye) - erythromycin ophthalmic ointment & warm wet compresses to eye shld fix.Go 2 ur Dr.plz...
baylahi (Bayla Highland) Sat, 07 Nov 2009 17:14:57 -0000
@1capplegate lookin like a hordeolum (Stye) - erythromycin ophthalmic ointment & warm wet compresses to eye shld fix.Go 2 ur Dr.plz...
Inspire ups production of AzaSite during erythromycin ophthalmic ointment shortage: http://ow.ly/zTHu
OSNSuperSite (The OSN SuperSite) Sat, 07 Nov 2009 06:45:07 -0000
Inspire ups production of AzaSite during erythromycin ophthalmic ointment shortage: http://ow.ly/zTHu
Right, off to the pharmacy to (finally) pick up some new anitbiotics (hopefully these will be a lot better than the erythromycin).
cymruangel (Hannah Thomas) Fri, 06 Nov 2009 16:09:14 -0000
Right, off to the pharmacy to (finally) pick up some new anitbiotics (hopefully these will be a lot better than the erythromycin).
Erythromycin works best para sa bad micro organisms na dulo't ng climate change.
NaniNaguit (Nani Naguit) Fri, 06 Nov 2009 03:39:57 -0000
Erythromycin works best para sa bad micro organisms na dulo't ng climate change.
Erythromycin, ampicillin, gentamicin, ciprofloxacin, penicillin, vancomycin. So fun.
missrena (Rena Rau) Thu, 05 Nov 2009 15:28:08 -0000
Erythromycin, ampicillin, gentamicin, ciprofloxacin, penicillin, vancomycin. So fun.
Warning Against Using Erythromycin (Even Orally) While Using... http://tinyurl.com/yf3ktmq
mariss4qxt (Marissa Rogers) Thu, 05 Nov 2009 05:57:12 -0000
Warning Against Using Erythromycin (Even Orally) While Using... http://tinyurl.com/yf3ktmq

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