Erythromycin is a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Structurally, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desoamine), making it a compound very difficult to produce via synthetic methods.
Erythromycin is produced from a strain of the actinomyces Saccaropolyspora erythraea, formerly known as Streptomyces erythraeus.
History
Abelardo Aguilar, a Filipino scientist, sent some soil samples to his employer
Eli Lilly in
1949. Eli Lilly’s research team, led by J. M. McGuire, managed to isolate Erythromycin from the metabolic products of a strain of
Streptomyces erythreus (designation changed to "
Saccharopolyspora erythraea") found in the samples. Lilly filed for patent protection of the compound and U.S. patent 2,653,899 was granted in 1953. The product was launched commercially in
1952 under the brand name
Ilosone® (after the
Philippine region of
Iloilo where it was originally collected from). Erythromycin was formerly also called
Ilotycin®. In 1981, Nobel laurate (1965 in chemistry) and Professor of Chemistry at
Harvard University (
Cambridge, MA)
Robert B. Woodward and a large team of researchers reported the first stereocontrolled asymmetric chemical synthesis of Erythromycin A.
The antiobiotic clarithromycin was invented by scientists at the Japanese drug company Taisho Pharmaceutical in the 1970s as a result of their efforts to overcome the acid instability of erythromycin.
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Erythromycin has practically stopped my coughing fits. Plus it reminds me of "The House Bunny" which makes me laugh!talentforsin (Jen) Fri, 18 Dec 2009 01:40:41 -0000
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DrugDigest: Erythromycin - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available. Sold under brand names such as: E-Base, E-Mycin, EES, Ery-Tab, EryPed, Erythrocin, Ilosone, and PCE Dispertab.
Emgel - Product information from Glaxo Wellcome, in Portable Document Format (PDF).
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Erythromycin Ethylsuccinate - Familydoctor.org - Information for patients in English and Spanish.