Eplerenone (INN) (IPA: ) is an aldosterone antagonist used as an adjunct in the management of chronic heart failure. It is similar to spironolactone, though it may be more specific for the mineralocorticoid receptor and is specifically marketed for reducing cardiovascular risk in patients following myocardial infarction. It is marketed by Pfizer under the trade name Inspra.

Clinical use

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Indications

Eplerenone is specifically indicated for the reduction of risk of cardiovascular death in patients with heart failure and left ventricular dysfunction within 3–14 days of an acute myocardial infarction, in combination with standard therapies.

Contraindications

Eplerenone is contraindicated in patients with hyperkalaemia, renal impairment, or severe hepatic impairment. The manufacturer of eplerenone also contraindicates concomitant treatment with ketoconazole, itraconazole or other potassium-sparing diuretics.

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eff of eplerenone & amlodipine on blood pressure & basal metabolic r8 in obse hypertensives http://bit.ly/8vAmy0
localtrials (US Clinical Trials ) Wed, 09 Dec 2009 12:54:55 -0000
eff of eplerenone & amlodipine on blood pressure & basal metabolic r8 in obse hypertensives http://bit.ly/8vAmy0
eff of eplerenone & amlodipine on blood pressure & basal metabolic r8 in obse hypertensives http://bit.ly/8vAmy0
usclinicaltrial (US Clinical Trials) Wed, 09 Dec 2009 12:42:53 -0000
eff of eplerenone & amlodipine on blood pressure & basal metabolic r8 in obse hypertensives http://bit.ly/8vAmy0
eff of eplerenone & amlodipine on blood pressure & basal metabolic r8 in obse hypertensives http://bit.ly/8vAmy0
recruitingtrial (Recruiting Trials) Wed, 09 Dec 2009 11:06:53 -0000
eff of eplerenone & amlodipine on blood pressure & basal metabolic r8 in obse hypertensives http://bit.ly/8vAmy0
comp of outcomes in ppl in new york heart association class ii heart failure when tre8d w/ eplerenone or placebo in http://bit.ly/6GaOIm
paidtrials (US Clinical Trials) Tue, 08 Dec 2009 05:19:00 -0000
comp of outcomes in ppl in new york heart association class ii heart failure when tre8d w/ eplerenone or placebo in http://bit.ly/6GaOIm
#pharmacy Timing of Eplerenone Initiation and Outcomes in Patients with Heart Failure after Acute Myocardial Infarcti.. http://bit.ly/7RWAGv
bookapharmacist (Kazeem Olalekan) Fri, 04 Dec 2009 15:33:47 -0000
#pharmacy Timing of Eplerenone Initiation and Outcomes in Patients with Heart Failure after Acute Myocardial Infarcti.. http://bit.ly/7RWAGv
comp of outcomes in ppl in new york heart association class ii heart failure when tre8d w/ eplerenone or placebo in http://bit.ly/6GaOIm
localtrials (US Clinical Trials ) Fri, 04 Dec 2009 09:38:42 -0000
comp of outcomes in ppl in new york heart association class ii heart failure when tre8d w/ eplerenone or placebo in http://bit.ly/6GaOIm

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