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Eflornithine (α-difluoromethylornithine or DFMO) is a drug manufactured by Sanofi-Aventis which has various uses. It was initially developed as a cancer medication; and while it has no significant effects on cancerous malignancies, it was found to be very effective in combatting African trypanosomiasis (sleeping sickness), in its West African form (Trypanosoma brucei gambiense)Pepin J, Milord F, Guern C, Schechter PJ. Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness. Lancet 1987;2(8573):1431-3. PMID 2891995.
Sleeping sickness treatment
Function
Eflornithine appears to kill trypanosomes by acting as a suicide inhibitor of the enzyme ornithine decarboxylase (), this enzyme regulates cell division by catalysing the first step in polyamine biosynthesis.Eflornithine's effects against Trypanosoma brucei gambiense were discovered by chance and because its ability to bring patients back from coma, it became known as "Resurrection Drug".
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