Doxepin is a tricyclic antidepressant, known under many brand-names such as Aponal®, the original preparation by Boehringer-Ingelheim, now part of the Roche group; Adapine®, Sinquan® and Sinequan® (Pfizer Inc.). As doxepin hydrochloride it is the active ingredient in cream based preparations (Zonalon® and Xepin®) for the treatment of dermatological itch.

Pharmacology

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Doxepin inhibits the reuptake of serotonin and noradrenaline from the synaptic cleft (dual action). The reuptake-inhibition of dopamine is very weak.

It has antagonistic effects (blockade) on a variety of postsynaptic receptors:

• Extremely strong : H1, H2
• Strong : 5-HT2, Alpha1, Muscarinic
• Moderate : 5-HT1
• Weak : D2, Alpha2

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Lexapro, Doxepin Hydrochloride interactions for a female aged 19 W/ Depression, Insomnia - eHealthMe http://bit.ly/7fvvAv
drugsideeffects (drug side effects) Wed, 06 Jan 2010 04:51:05 -0000
Lexapro, Doxepin Hydrochloride interactions for a female aged 19 W/ Depression, Insomnia - eHealthMe http://bit.ly/7fvvAv
Doxepin Hydrochloride side effects for a male aged 46 W/ Sleep - natural short sleeper - eHealthMe http://bit.ly/5FgjK2
eHealthMe (eHealthMe.com) Sun, 03 Jan 2010 18:58:15 -0000
Doxepin Hydrochloride side effects for a male aged 46 W/ Sleep - natural short sleeper - eHealthMe http://bit.ly/5FgjK2
Doxepin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References | http://tinyurl.com/y99al6z
ONEJOBSTOP (Ramzi Aydi) Thu, 31 Dec 2009 01:42:10 -0000
Doxepin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References | http://tinyurl.com/y99al6z
last night night cap consisted of bong hits, 25mg benadryl, 40mg doxepin, 1mg ativan etcetera, how am i awake right now?
o_OemmaO_o (emma) Wed, 30 Dec 2009 17:23:45 -0000
last night night cap consisted of bong hits, 25mg benadryl, 40mg doxepin, 1mg ativan etcetera, how am i awake right now?

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