Doxapram hydrochloride (marketed as Dopram®) is an analeptic agent (a stimulant of the central nervous system). Administered intravenously, doxapram stimulates the respiratory rate, leading to an increase in tidal volume.

Mode of action

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Doxapram stimulates chemoreceptors in the carotid arteries. This stimulates, indirectly, the respiratory centre in the brain stem.

Presentation

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Doxapram is a white to off-white, odorless, crystalline powder that is stable in light and air. It is soluble in water, sparingly soluble in alcohol and practically insolible in ether. Injectable products have a pH from 3.5-5. Benzyl alcohol or chlorobutanol is added as a preservative agent in the commercially available injections.

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