Diflunisal is a generic NSAID (Non Steroidal Anti Inflammatory Drug). It is often used under the brand name Dolobid® marketed by Merck & Co.. Diflunisal acts by inhibiting the production of prostaglandin, a hormone that creates inflammation and stimulates the neuro receptors for pain. Though Diflunisal has an onset of 1 hour, and maximum analgesia at 2 to 3 hours, the diflunisal plasma levels will not be steady until repeated doesages are achieved. To increase the rate at which the diflunisal plasma levels become steady, a loading dose is usually used. It is primarily used to treat symptoms of arthritis.

Overdose

---

Deaths that have occurred from Diflunisal usually involved mixed drugs and or extremely high dosages. The oral LD50 is 500mg/kg. Symptoms of overdose include, coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. Mixed with other medicines, a death at 7.5 grams has also occurred. Diflunisal usually comes in 250 or 500mg, thus it is relatively hard to overdose by accident.

External links

---

More on [ Diflunisal ]

Subscribe to Diflunisal RSS feed