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Estradiol (17β-estradiol) (also oestradiol) is a sex hormone. Labelled the "female" hormone but also present in males it represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including bone structure.
Synthesis
Estradiol, like other sex steroids, is derived from cholesterol. After side chain cleavage and utilizing the delta-5 pathway or the delta-4 pathway androstenedione is the key intermediary. Androstendione is either converted to testosterone which in turn undergoes aromatization to estradiol, or, alternatively, androstendione is aromatized to estrone which is converted to estradiol.
Production
During the reproductive years most estradiol in women is produced by the granulosa cells of the ovaries by aromatization of testosterone from the theca cells, or conversion of estrone to estradiol. Smaller amounts of estradiol are also produced by the adrenal cortex. In men, the testes produce estradiol. More on [ Estradiol ]
DrugDigest: Desogestrel and Ethinyl Estradiol - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available. Sold under brand names such as: Apri, Cyclessa, Desogen, Kariva, Mircette, and Ortho-Cept.
MedlinePlus: Estrogens and Progestins Oral Contraceptives (Systemic ) - Features information about dosage, usage, warnings, and side effects.
Meta Description: [ Estrogens and Progestins Oral Contraceptives(Systemic) ]
Mircette - Drug review and approval details from the FDA. [Acrobat Reader required]
| Higher Estrogen Exposure with Ortho Evra Patch (Apr. 2008) | |
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