Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin® and Pertofrane®. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine.

Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect.

Some evidence suggests that desipramine may help with ADD.

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الأدوية العصبية مثل Carbamazepine Clonazepam Ethosuximide Gabapentin Lamotrigine .. مضادات الإكتئاب مثل Amitriptyline Desipramine ...2
Dr_7aman (AbdulRahman bin T) Fri, 13 Jan 2012 16:43:58 -0000
الأدوية العصبية مثل Carbamazepine Clonazepam Ethosuximide Gabapentin Lamotrigine .. مضادات الإكتئاب مثل Amitriptyline Desipramine ...2
Photo: desipramine: http://t.co/g7t35xep
DemiMyGoddess (Biscoitinha da Demi ) Wed, 11 Jan 2012 02:02:20 -0000
Photo: desipramine: http://t.co/g7t35xep
Amitriptyline, desipramine, nortriptyline, imipramine may cause tachycardia, bradycardia, ventricular arrhythmias,
ACLSAdvisor (Current Clinical Str) Sun, 08 Jan 2012 05:39:17 -0000
Amitriptyline, desipramine, nortriptyline, imipramine may cause tachycardia, bradycardia, ventricular arrhythmias,

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