Dantrolene sodium is a muscle relaxant that is currently the only specific and effective treatment for malignant hyperthermia. It is also used in the management of neuroleptic malignant syndrome, muscle spasticity (e.g. after strokes, in paraplegia, cerebral palsy, or patients with multiple sclerosis) and ecstasy intoxication.

Chemistry

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Chemically it is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.

The related substance azumolene is under development for similar indications. It has a bromine residue instead of the nitrite group, and is 30 times more water-soluble.

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JHP Pharm Introduces a Dantrium(R) IV (dantrolene sodium for injection)http://www.centredaily.com/463/story/1532124.html @centredailycom
JustinHOPE (Dale Ann Micalizzi) Wed, 30 Sep 2009 20:50:37 -0000
JHP Pharm Introduces a Dantrium(R) IV (dantrolene sodium for injection)http://www.centredaily.com/463/story/1532124.html @centredailycom
JHP Pharmaceuticals Introduces A Dantrium(R) IV (dantrolene Sodium For Injection), Rapidly Mixing At 20 Seconds http://bit.ly/35Ej8g
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JHP Pharmaceuticals Introduces a Dantrium(R) IV (dantrolene sodium ... - PR Newswire (press release) (http://cli.gs/DnNVy)
dfcvBlogsNew (John Doe) Tue, 29 Sep 2009 05:01:32 -0000
JHP Pharmaceuticals Introduces a Dantrium(R) IV (dantrolene sodium ... - PR Newswire (press release) (http://cli.gs/DnNVy)

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