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Co-trimoxazole (abbreviated SXT, TMP-SMX, or TMP-sulfa) is an antibiotic combination of trimethoprim and sulfamethoxazole, in the ratio of 1 to 5, used in the treatment of a variety of bacterial infections. The name co-trimoxazole is the British Approved Name, and has been marketed worldwide under many trade names including Septrin (GSK), Bactrim (Roche), and various generic preparations. According to the American Hospital Formulary Service, "co-trimoxazole usually is bactericidal." Other sources list this antibiotic as bacteriostatic.
Synergistic action
Co-trimoxazole exhibits a synergistic antibacterial effect when compared to each of its components administered singly. This is because trimethoprim and sulfamethoxazole inhibit successive steps in the folate synthesis pathway (see diagram below).
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Antibiotics :: Drugs and Medications
drank the wrong drug. Cotrimoxazole instead of cefalexin. Will i die?
ronvil (ronvil) Fri, 06 Nov 2009 13:47:24 -0000
drank the wrong drug. Cotrimoxazole instead of cefalexin. Will i die?
DrugDigest: Cotrimoxazole - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available. Sold under brand names sush as: Bactrim, Cotrim, Septra, and Sulfatrim.
TMP-SMX (Bactrim) - Trimethoprim-Sulfamethoxazole, TMP-SMX, Septra.
