Clozapine (sold as Clozaril®, Leponex®, Fazaclo®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia.

History and main uses

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Clozapine was developed by Sandoz in 1961, and introduced in Europe ten years later. In 1975, after reports of agranulocytosis leading to death in some clozapine-treated patients, Clozapine was voluntarily withdrawn by the manufacturer. Clozapine fell out of favor for more than a decade. However, when studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics, the FDA and health authorities in most other countries approved its use only for treatment-resistant schizophrenia, and required regular haematological monitoring to detect granulocytopenia, before agranulocytosis develops. In December of 2002, Clozapine was also approved for reducing the risk of suicide in schizophrenic or schizoaffective patients judged to be at chronic risk for suicidal behavior.

Commonly approved indications

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• Treatment-resistant schizophrenia, if the required hematologic monitoring is adhered to
• Reducing the risk of suicide in schizophrenic or schizoaffective patients judged to belong to a high risk group with chronic risk for suicidal behavior. Clozapine was shown to prolong the time to suicidal attempt significantly greater than Olanzapine (Zyprexa®).

More on [ Clozapine ]

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Based on 23,758 reports, Clozapine side effects in real world - eHealthMe http://tinyurl.com/yj7phyk
eHealthMe (eHealthMe.com) Tue, 05 Jan 2010 21:47:36 -0000
Based on 23,758 reports, Clozapine side effects in real world - eHealthMe http://tinyurl.com/yj7phyk
Converting from brand-name to generic clozapine: A review of effectiveness and tolerability .Am Jof Health-System Pharm http://bit.ly/6QiOc0
PharmacoBlogie (PharmacoBlogie) Tue, 05 Jan 2010 19:19:19 -0000
Converting from brand-name to generic clozapine: A review of effectiveness and tolerability .Am Jof Health-System Pharm http://bit.ly/6QiOc0
Converting from brand to generic clozapine doesn't appear to have any major adverse effects- Source: Am J Health-Sy... http://bit.ly/4Grc4Y
Bipolar_Blogs (Bipolar Blogs) Tue, 05 Jan 2010 17:03:19 -0000
Converting from brand to generic clozapine doesn't appear to have any major adverse effects- Source: Am J Health-Sy... http://bit.ly/4Grc4Y
examples of psychological drugs: chlorapromazine, clozapine, fluoxetine, etc. how an i suppose to remember this?
karin903 (Karin Soyama) Sun, 03 Jan 2010 03:38:51 -0000
examples of psychological drugs: chlorapromazine, clozapine, fluoxetine, etc. how an i suppose to remember this?
Converting from brand-name to generic clozapine: A review of effectiveness and tolerability data.- Converti... http://bit.ly/7SaYYi
Bipolar_Blogs (Bipolar Blogs) Sat, 02 Jan 2010 12:13:00 -0000
Converting from brand-name to generic clozapine: A review of effectiveness and tolerability data.- Converti... http://bit.ly/7SaYYi
@dyelirious yea i mean they offered me like Clozapine and all that shit but i just want antianxiety
xthecrazygoatx (xthecrazygoatx) Tue, 29 Dec 2009 13:43:27 -0000
@dyelirious yea i mean they offered me like Clozapine and all that shit but i just want antianxiety

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