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Clopidogrel (IPA: ) is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi-Aventis under the trade name Plavix.
Pharmacology
The mechanism of action of clopidogrel is irreversible blockade of the adenosine diphosphate (ADP) receptor on platelet cell membranes. This receptor is named P2Y12 and is important in platelet aggregation, the cross-linking of platelets by fibrin. The blockade of this receptor inhibits platelet aggregation by blocking activation of the glycoprotein IIb/IIIa pathway.
Platelet inhibition can be demonstrated two hours after a single dose of oral clopidogrel.
More on [ Clopidogrel ]
Plavix - Indicated for the reduction of atherosclerotic events (myocardial infarction, stroke and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Meta Description: [ PLAVIX is indicated for patients with recent heart attack, recent stroke, or poor circulation in the legs, known as peripheral arterial disease (PAD), and for patients who have been hospitalized with heart-related chest pain or acute coronary syndrome (ACS). ]
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