Clonazepam (marketed by Roche under the trade-name Klonopin® in the United States and Rivotril® in Europe, South America and Canada) is a drug which is a benzodiazepine derivative. It is a highly potent anticonvulsant, amnestic and anxiolytic.
Pharmacology
Like other benzodiazepines, clonazepam is believed to act by simulating the action of GABA on the central nervous system. Because of strong anxiolytic properties and euphoric side-effects it is said to be among the class of 'highly potent' benzodiazepines with a higher risk of abuse, misuse and dependence than other benzodiazepines, excluding alprazolam which alone is considered to be the most potent. The sedative effects of clonazepam are relatively weak, compared to its strong anxiolytic and anticonvulsant effects. One quarter of a milligram (0.25mg) of clonazepam is approximately equivalent to five milligrams (5.00mg) of diazepam.
Tourette Syndrome - Clonazepam has shown to be helpful in reducing and dealing with the physical motor tics associated with TS, though is still considered an off-label usage by many.
WL Issued to Amrex Zetron Inc FDA Tue, 14 Apr 2009 00:00:00 -0400 FDA Warning Letter Issued to Amrex Zetron Inc on 14 Apr 2009 by Los Angeles District Office WL Issued to Coast Institutional Review Board FDA Tue, 14 Apr 2009 00:00:00 -0400 FDA Warning Letter Issued to Coast Institutional Review Board on 14 Apr 2009 by Center for Drug Evaluation and Research WL Issued to Branitz, Bruce, MD FDA Thu, 09 Apr 2009 00:00:00 -0400 FDA Warning Letter Issued to Branitz, Bruce, MD on 09 Apr 2009 by Center for Drug Evaluation and Research WL Issued to Cote, Charles J., MD FDA Mon, 02 Mar 2009 00:00:00 -0400 FDA Warning Letter Issued to Cote, Charles J., MD on 02 Mar 2009 by Center for Drug Evaluation and Research WL Issued to Genzyme Corporation FDA Fri, 27 Feb 2009 00:00:00 -0400 FDA Warning Letter Issued to Genzyme Corporation on 27 Feb 2009 by New England District Office WL Issued to Hammill Manufacturing Company FDA Tue, 06 Jan 2009 00:00:00 -0400 FDA Warning Letter Issued to Hammill Manufacturing Company on 06 Jan 2009 by Cincinnati District Office
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WL Issued to Coast Institutional Review Board FDA Tue, 14 Apr 2009 00:00:00 -0400 FDA Warning Letter Issued to Coast Institutional Review Board on 14 Apr 2009 by Center for Drug Evaluation and Research WL Issued to Branitz, Bruce, MD FDA Thu, 09 Apr 2009 00:00:00 -0400 FDA Warning Letter Issued to Branitz, Bruce, MD on 09 Apr 2009 by Center for Drug Evaluation and Research WL Issued to Bukowski, Ronald M, MD FDA Mon, 30 Mar 2009 00:00:00 -0400 FDA Warning Letter Issued to Bukowski, Ronald M, MD on 30 Mar 2009 by Center for Drug Evaluation and Research WL Issued to Youabian, Inc FDA Tue, 17 Mar 2009 00:00:00 -0400 FDA Warning Letter Issued to Youabian, Inc on 17 Mar 2009 by Los Angeles District Office WL Issued to Provena St. Joseph's Medical Center IRB FDA Thu, 12 Mar 2009 00:00:00 -0400 FDA Warning Letter Issued to Provena St. Joseph's Medical Center IRB on 12 Mar 2009 by Center for Biologics Evaluation and Research WL Issued to Paulson, Daniel M., MD FDA Wed, 11 Mar 2009 00:00:00 -0400 FDA Warning Letter Issued to Paulson, Daniel M., MD on 11 Mar 2009 by Center for Drug Evaluation and Research
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