Clomipramine (brand-name Anafranil®) is a tricyclic antidepressant.

Indications

• Depression with lack of energy or mild agitation
• Obsessive Compulsive Disorders (OCD)
• Panic attacks with or without Agoraphobia
• Narcolepsy
• chronic pain with or without organic disease, particular headache of the tension type
• Enuresis (involuntary nightly urinating in sleep) in children / adolescents
• Off label, sometimes antidepressants of this type have been found helpful in reducing relapses in cocaine addicts and to help repair cocaine-caused neurotransmitter imbalances and early brain damage. Further studies are needed for Clomipramine in this regard.

It may take 2 to 3 weeks before the full effects of this medication are noticed in all indications.