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Clomifene (INN) or clomiphene (USAN and former BAN) is a selective estrogen receptor modulator (SERM), used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome). In some countries, it is also registered for use in men. Clomifene citrate is marketed under various trade names including Clomid®, Serophene®, Milophene®, etc.
Mode of action
Clomifene acts by inhibiting the action of estrogen on the gonadotrope cells in the anterior pituitary gland. "Sensing" low estrogen levels, follicle-stimulating hormone (FSH) release is increased, leading to a higher rate of ovulation and hence pregnancy.
Clomifene can lead to multiple ovulation, and hence increasing the risk of twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer, and weight gain.
More on [ Clomifene ]
Infertility :: Reproductive Health
Women's Health
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Fertility drug: Clomiphene - Brand names, conditions in women and men for which it might be helpful, what treatment is like, side effects, success rates, estimate of minimum cost for monthly prescription.
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Meta Description: [ Clomid is used for ovulation induction as a first choice drug. Clomiphene is prescribed for three months. ]
MesoRx: Clomiphene Citrate (Clomid) - An article on the usefulness of clomiphene as an anti-estrogen for male bodybuilders and endurance athletes.
Multum Information Services: Clomiphene - FAQ for consumers covers symptoms of an overdose, who should not take this medication, what it does, and other questions.
Women's Health, UK: Clomiphene citrate (clomid) - Simple explanation of the most important things for women to know about this drug. In question-and-answer form.
Meta Description: [ Clomiphene is commonly used for first-line ovarian stimulation in anovulatory infertility. A discussion of its use, side effects and success rates. ]
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