Clemastine, also known as meclastin, is an antihistamine drug. Unlike loratadine or fexofenadine, clemastine is a sedating antihistamine, however it exhibits fewer side effects than most of the widely used antihistamines. Clemastine is also classified as an antipruritic (i.e. it stops itching).

Pharmacology

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Clemastine is an antihistamine with anticholinergic and sedative effects. Antihistamines competitively bind to histamine receptor sites, thus reducing the neurotransmitter's effects. Effects of histamine (which are countered by antihistamines) include:

• Increased capillary permeability
• Increased capillary dilatation
• Edema (i.e. swelling)
• Pruritus
• Gastrointestinal/respiratory smooth muscle constriction

Clemastine inhibits both the vasoconstrictor and vasodilator effects of histamine. Depending on the dose, the drug can produce paradoxical effects, including CNS stimulation or depression.

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