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Cisapride
cis-4-amino-5-chloro-N-*-3-methoxy-4-piperidinyl]-
2-methoxybenzamide
CAS number
81098-60-4
ATC code
A03FA02
Chemical formula C23H29ClFN3O4
Molecular weight 465.9
Bioavailability ~100%
Metabolism hepatic, intestinal
Elimination half life 10 hours
Excretion renal, biliary
Pregnancy category B1 (Australia)
Legal status Schedule 4 (Australia)
Delivery tablets, suspension
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It is sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.).

Clinical uses


Cisapride increases muscle tone in the esophageal sphincter in people with gastroesophageal reflux disease. It also increases gastric emptying in people with diabetic gastroparesis. It has been used to treat bowel constipation.

In many countries it has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias.

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who makes Cisapride and when was it made first? http://bit.ly/5tdkhr
hotmailhamdi (huhun juran) Tue, 22 Dec 2009 06:47:20 -0000
who makes Cisapride and when was it made first? http://bit.ly/5tdkhr
what is Cisapride and about its side effect, complications, dosage, who is it for, place to buy it, http://bit.ly/6CCmLV
hotmailhamdi (huhun juran) Fri, 18 Dec 2009 13:17:33 -0000
what is Cisapride and about its side effect, complications, dosage, who is it for, place to buy it, http://bit.ly/6CCmLV

 
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Cisapride and Arrhythmias - New Zealand government safety bulletin.

DrugDigest: Cisapride ( Propulsid ) - Information on dosage, usage, side effects, interactions, and drug comparisons.

Medicines Control Agency announces withdrawal of Cisapride - Letter withdrawing Cisapride (Prepulsid) from the UK.
Meta Description: [ The Medicines Control Agency (MCA) today announced the suspension of product licences for cisapride (Prepulsid- Janssen Cilag) with its consequent withdrawal effective from 28 July 2000. ]

Propulsid Warning - Notification of important changes in the U.S. FDA Propulsid labeling to reflect new safety information, including recommendations for performing diagnostics tests prior to any use.
Meta Description: [ DESCRIBE CONTENTS ]

404 Use of Cisapride in Children - A Medical Position Statement of the North American Society for Pediatric Gastroenterology and Nutrition. Discusses the risks and benefits of this medication for treating gastroesophageal reflux and other conditions.

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